introduction: the glutamatergic system plays an important role in learning and memory. administration of crocus sativus (saffron) or its constituent, crocin, facilitates the formation of memory. this research investigated the effect of crocin on antagonizing retrograde amnesia induced by ketamine, a glutamatergic receptor antagonist, in rats by shuttle box. methods:  male wistar rats were teste...

introduction: biological effects of magnetic fields have been investigated by scientists for many years and a vast amount of research using different frequencies and intensities have been performed on humans and laboratory animals. the results of these studies, which have mostly been done by applying high frequencies, have shown that electromagnetic fields are effective on structure and functio...

introduction: estrogen is one of the gonadal hormones that has multiple beneficial actions in central nervous system and involves in learning and memory. alzheimer's disease (ad) is a progressive neurodegenerative disorder that impairs patient memory. the human nucleus basalis of meynert (nbm) is severely affected in alzheimer's disease. so in this study the effect of peripheral (intr...

introduction: aluminum is known as a neurotoxic element which causes neurodegeneration, learning deduction and movement disorders. aluminum ions in the brain cause serious problems such as alzheimer, parkinson and other degenerative diseases. on the other hand, zinc is a dietary element essential for several biological processes, modulates neurotransmission in brain regions and associates with ...

objective(s): auraptene (7-geranyloxycoumarin) (aur), from citrus species has shown anti-inflammatory, neuroprotective, and acetylcholinesterase (ache) and beta-secretase inhibitory effects. scopolamine is a nonselective muscarinic receptor antagonist which causes short-term memory impairments and is used for inducing animal model of alzheimer’s disease (ad). this research aimed to investigate ...

Dogs which had 1st learned to panel press in a harness in order to escape shock subsequently showed normal acquisition of escape/ avoidance behavior in a shuttle box. In contrast, yoked, inescapable shock in the harness produced profound interference with subsequent escape responding in the shuttle box. Initial experience with escape in the shuttle box led to enhanced panel pressing during ines...

introduction: learning and memory deficits in some diseases are new subjects of research. bupropion, as dopamine and noradrenaline reuptake inhibitor and an antidepressant agent, has been previously shown to affect learning and memory processes. this study was designed to test the effect of intra-hippocompal bupropion injection on active avoidance learning task in rats. methods: adult male wist...

introduction: butylated hydroxytoluene (bht 2, 6-di-tert-butyl-p-cresol) is one of the extensively used antioxidants in the food industry. it is used in low-fat foods, fish products, packaging materials, paraffin, and mineral oils. bht is also widely used in combination with other antioxidants such as bha, propyl gallate, and citric acid for the stabilization of oils and high-fat foods. on the ...

some animal models have been used to study alzheimer's disease (ad). ad is an irreversible progressive neurodegenerative disease and the most common cause of dementia. animal studies have shown that there is a relation between decrease in cholinergic functions in the nucleus basalis of meynert (nbm) and loss of learning capability and memory. the aim of this study was to investigate the ef...